Article

Abnormal Rat Cortical Development Induced by Ventricular Injection of rHMGB1 Mimicked the Pathophysiology of Human Cortical Dysplasia

2020-12-01

Abstract excerpt

<h4>Background: </h4> Cortical dysplasia (CD) is a common cause of drug-resistant epilepsy. Increasingly, innate immunity is involved in CD with epilepsy. However, it is unclear whether innate immune factors contribute to induce epileptogenic CD. Here, we injected recombinant human HMGB1 (rHMGB1) into the embryonic rat ventricle to determine whether rHMGB1 can induce epileptogenic CD with pathophysiological charac...

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Literature Corpus work: 3a392f86-26b2-5b2e-bc96-bee61bf3fbb0
DOI: 10.21203/rs.3.rs-115999/v1

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