Article

PI3K/mTOR and topoisomerase inhibitors with potential activity against SARS-CoV-2 infection

2020-09-03

Abstract excerpt

There is an urgent need to identify therapies to prevent and treat SARS-CoV-2 infection. We performed a statistical evaluation of in vitro gene expression profiles reflecting exposure to 1,835 drugs, and found topoisomerase inhibitors and PI3K/mTOR pathway inhibitors among the strongest candidates for reduced expression of ACE2, a host gene associated with SARS-CoV-2 infection. Retrospective clinical data suggest...

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Literature Corpus work: 3a308c2a-67f3-5899-9c11-c1a0ab894feb
DOI: 10.1101/2020.09.02.20186783

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