Article

Analysis of Infected Host Gene Expression Reveals Repurposed Drug Candidates and Time-Dependent Host Response Dynamics for COVID-19

2020-04-09

Abstract excerpt

<h4>Summary</h4> The repurposing of existing drugs offers the potential to expedite therapeutic discovery against the current COVID-19 pandemic caused by the SARS-CoV-2 virus. We have developed an integrative approach to predict repurposed drug candidates that can reverse SARS-CoV-2-induced gene expression in host cells, and evaluate their efficacy against SARS-CoV-2 infection in vitro . We found that 13 virus-i...

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Literature Corpus work: 041118f7-ad88-518c-864f-74853f2914a8
DOI: 10.1101/2020.04.07.030734

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