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Article

Circadian Clock Regulation of Developmental Time in the Kidney

1 May 2020

Abstract excerpt

We report the emergence of an endogenous circadian clock that regulates organogenesis in mouse fetal kidney. We detect circadian rhythms both in vivo with transcriptional profiling and ex vivo by bioluminescence. High-resolution structural analysis of embryonic explants reveals that global or local clock disruption results in defects that resemble human congenital abnormalities of the kidney. The onset of fetal...

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PMID: 32433970
DOI: 10.1016/j.celrep.2020.107661

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