Article

Defining the mechanistic role of high mobility group box-1 and its utility as a biomarker in the inflammatory pathogenesis of epilepsy

2015-01-01

Abstract excerpt

Epilepsy, which affects 50 million people worldwide, is a chronic neurological condition characterized by a predisposition to generate spontaneous seizures. Antiepileptic drug resistance is a significant problem, the causes of which are poorly understood. Inflammation is purported to play a pathological role in the development of epilepsy following brain insult. High mobility group box-1 (HMGB1) has been implicate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a199bfe-7e2d-50f2-bcea-2a9e2030e2b4
DOI: 10.17638/02018620

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining the mechanistic role of high mobility group box-1 and its utility as a biomarker in the inflammatory pathogenesis of epilepsyDOI 10.17638/02018620Read

High Mobility Group Box 1 (HMGB1): Molecular Signaling and Potential Therapeutic StrategiesSemantic proximity Read

Persistent DNA methylation and downregulation of homeostatic genes in astrocytes after pilocarpine-induced status epilepticus: Implications for epileptogenesisSemantic proximity Read

Emerging Roles of High-mobility Group Box-1 in Liver DiseaseSemantic proximity Read

HMGB1-TLR4 Axis Plays a Regulatory Role in the Pathogenesis of Mesial Temporal Lobe Epilepsy in Immature Rat Model and Children via the p38MAPK Signaling PathwaySemantic proximity Read

HMGB1: An overview of its roles in the pathogenesis of liver diseaseSemantic proximity Read

Personalized medicine approaches in epilepsy.Semantic proximity Read

Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver DiseasesSemantic proximity Read

Emerging roles for HMGB1 protein in immunity, inflammation, and cancerSemantic proximity Read

High mobility group box 1 (HMGB1): a pivotal regulator of hematopoietic malignanciesSemantic proximity Read

Integrated Mendelian Randomization and Single‐Cell Transcriptomics Analysis Identifies Critical Blood Biomarkers and Potential Mechanisms in EpilepsySemantic proximity Read

Immunologic and Neuroinflammatory Bases of Epileptogenesis: Personalized Therapeutic OptionsSemantic proximity Read

Association of genetic polymorphism of pre-microRNA-146a rs2910164 and serum high-mobility group box 1 with febrile seizures in Egyptian children.Semantic proximity Read