Article

Selenoprotein S deficiency induces matrix degradation via TGF-β pathway leading to cartilage damage

2026-04-27

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> The deficiency of trace element selenium is a global nutritional issue. Selenium exerts its biological functions in the human body through selenoproteins, which play crucial roles in bone and cartilage development. Selenoprotein S (SelS), a key selenoprotein involved in the regulation of oxidative stress and inflammation, has an unclear role in cartilage deve...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3a0e698e-09d6-5ce0-965b-fbaad9eec218
DOI: 10.21203/rs.3.rs-9267022/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Selenoprotein S deficiency induces matrix degradation via TGF-β pathway leading to cartilage damageDOI 10.21203/rs.3.rs-9267022/v1Read

Osteo-Chondroprogenitor–Specific Deletion of the Selenocysteine tRNA Gene, Trsp, Leads to Chondronecrosis and Abnormal Skeletal Development: A Putative Model for Kashin-Beck DiseaseSemantic proximity Read

Chondroprotective effects of bone marrow mesenchymal stem cell- derived exosomes in osteoarthritisSemantic proximity Read

Effects of the Leptin-Mediated MAPK/ERK Signaling Pathway on Collagen II Expression in Knee Cartilage of Newborn Male Mice from Obese Maternal OffspringSemantic proximity Read

Matrix Metalloproteinase 3: A Promoting and Destabilizing Factor in the Pathogenesis of Disease and Cell DifferentiationSemantic proximity Read

Proteoglycans in health and disease: emerging concepts and future directionsSemantic proximity Read

Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling.Semantic proximity Read

SERPINA3 is a marker of cartilage differentiation and is essential for the expression of extracellular matrix genes during early chondrogenesisSemantic proximity Read

Association study between polymorphisms in selenoprotein genes and susceptibility to Kashin-Beck disease.Semantic proximity Read

SOX9 is a regulator of ADAMTSs-induced cartilage degeneration at the early stage of human osteoarthritisSemantic proximity Read

Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factorsSemantic proximity Read

Selenoprotein function and muscle disease.Semantic proximity Read

Selenium Supplementation Influences Mice Testicular Selenoproteins Driven By Gut MicrobiotaSemantic proximity Read