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Article

Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-β signaling.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Nov 2012

Holz Jonathan D, Beier Eric, Sheu Tzong-Jen, Ubayawardena Resika, Wang Meina, Sampson Erik R, Rosier Randy N, Zuscik Michael, Puzas J Edward

Abstract excerpt

Lead remains a significant environmental toxin, and we believe we may have identified a novel target of lead toxicity in articular chondrocytes. These cells are responsible for the maintenance of joint matrix, and do so under the regulation of TGF-β signaling. As lead is concentrated in articular cartilage, we hypothesize that it can disrupt normal chondrocyte phenotype through suppression of TGF-β signaling....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22517267
DOI: 10.1002/jor.22117
PMCID: PMC3839422

Genes

MMP13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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