Article

The Second-Generation Proteasome Inhibitor Ixazomib Enhances the Anticancer Effects of Gemcitabine or Fluorouracil in Pancreatic Cancer Cells

2022-03-01

Abstract excerpt

<h4>Background: </h4> Ixazomib (MLN9708) shows a better pharmacodynamic and pharmacokinetic feature than bortezomib as a second-generation proteasome inhibitor. Our study aims to examine the cytotoxic effects of MLN9708 alone or in combination with fluorouracil (5-FU) or gemcitabine in pancreatic cancer cells, and explore the possible molecular mechanism with MLN9708 in pancreatic cancer. <h4>Materials:</h4> In th...

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Literature Corpus work: 9cacd674-7707-5d44-8e30-ee3633e24e6f
DOI: 10.21203/rs.3.rs-1374979/v1

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