Article

Analysis of Chk2, ATM, NBS1, three proteins involved in the cellular response to DNA damage

2007-01-01

Abstract excerpt

In presence of damage to nuclear DNA, eukaryotic cells trigger a set of signal transduction pathways, which lead to the arrest of cell-cycle progression until repair has occurred, to the increase of DNA repair capacity or, in some cases to a controlled suicide (apoptosis). In human cells in presence of DNA damage Chk2 kinase protein is activated by ATM, the protein mutated in ataxia telangiectasia (AT), and target...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 39ec581d-1c7a-5287-822c-1eb7150dac1f
DOI: 10.21954/ou.ro.0000fa66

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Analysis of Chk2, ATM, NBS1, three proteins involved in the cellular response to DNA damageDOI 10.21954/ou.ro.0000fa66Read

Chk2 activation dependence on Nbs1 after DNA damage.Semantic proximity Read

NBS1 and its functional role in the DNA damage response.Semantic proximity Read

The NBS1-ATM Connection RevisitedSemantic proximity Read

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent Phosphorylation of Chk1 on Ser-317 in Response to Ionizing RadiationSemantic proximity Read

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.Semantic proximity Read

Molecular mechanisms regulating the G2 checkpoint induced after DNA damageSemantic proximity Read

CHK2 kinase--a busy messenger.Semantic proximity Read

A case report of a patient with microcephaly, facial dysmorphism, chromosomal radiosensitivity and telomere length alterations closely resembling "Nijmegen breakage syndrome" phenotype.Semantic proximity Read

Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?Semantic proximity Read

Cell cycle-dependent and ATM-independent expression of human Chk1 kinaseSemantic proximity Read

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.Semantic proximity Read

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis.Semantic proximity Read