Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?

13 Dec 2022

Abstract excerpt

There are a number of genetic syndromes associated with both high cancer risk and clinical radiosensitivity. However, the link between these two notions remains unknown. Particularly, some cancer syndromes are caused by mutations in genes involved in DNA damage signaling and repair. How are the DNA sequence errors propagated and amplified to cause cell transformation? Conversely, some cancer syndromes are caused...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Effects of Radiation Exposure

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36551628
DOI: 10.3390/cancers14246141

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer and Radiosensitivity Syndromes: Is Impaired Nuclear ATM Kinase Activity the Primum Movens?PMID 36551628Read ↗

The Nucleoshuttling of the ATM Protein: A Unified Model to Describe the Individual Response to High- and Low-Dose of Radiation?Semantic proximity Read ↗

Human Radiosensitivity and Radiosusceptibility: What Are the Differences?Semantic proximity Read ↗

Influence of Nucleoshuttling of the ATM Protein in the Healthy Tissues Response to Radiation Therapy: Toward a Molecular Classification of Human RadiosensitivitySemantic proximity Read ↗

DNA double-strand break repair defects in syndromes associated with acute radiation response: At least two different assays to predict intrinsic radiosensitivity?Semantic proximity Read ↗

Radiation, DNA damage and cancer.Semantic proximity Read ↗

DNA Damage Responses: Mechanisms and Roles in Human DiseaseSemantic proximity Read ↗

Molecular basis of ataxia telangiectasia and related diseases.Semantic proximity Read ↗

ATM&A Key Determinant of Multiple Cellular Responses to IrradiationSemantic proximity Read ↗

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes ApartSemantic proximity Read ↗

The versatile functions of ATM kinaseSemantic proximity Read ↗

Inhibition of ATM kinase activity does not phenocopy ATM protein disruptionSemantic proximity Read ↗

Radiotherapy and radiosensitivity syndromes in DNA repair gene mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.