Article

Loss of mitochondrial Chchd10 or Chchd2 in zebrafish leads to an ALS-like phenotype and Complex I deficiency independent of the mt-ISR

2022-05-02

Abstract excerpt

Mutations in CHCHD10 and CHCHD2 , coding for two paralogous mitochondrial proteins, have been identified in amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTD), and Parkinson’s disease (PD). Here we investigated the biological roles of these proteins during vertebrate development using knockout (KO) models in zebrafish. We demonstrate that loss of either or both proteins leads to a motor...

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Literature Corpus work: 3956ea00-fa5e-5ca1-b30d-ff69bca6564c
DOI: 10.1101/2022.05.02.488746

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