DHCR7 is a potential pan cancer biomarker for prognosis and immunotherapy

Abstract excerpt

<title>Abstract</title> <p>Background 7-dehydrocholesterol reductase (DHCR7) is a key enzyme involving the final step of cholesterol synthesis pathway. Abnormalities in the DHCR7 gene can lead to a variety of diseases, such as Smith-Lemli-Opitz syndrome. However, the relationship between DHCR7 and oncogenesis remain unclear. Methods We used several bioinformatic databases which the original data from the TCGA a...

Topics

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• Biomarkers, Tumor
• Gene Expression Regulation, Neoplastic
• Microsatellite Instability
• Mutation
• Neoplasms
• Oxidoreductases Acting on CH-CH Group Donors
• Prognosis
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

38fb9429-1f03-57a0-adf1-394ed97dbfcb

DOI

10.21203/rs.3.rs-4257606/v1