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Lactylation prognostic signature identifies DHCR7 as a modulator of chemoresistance and immunotherapy efficacy in bladder cancer

15 Jul 2025

Abstract excerpt

Background Bladder cancer (BLCA), the 10th most common cancer worldwide, presents a worsening prognosis as the disease progresses. Reliable tools for predicting BLCA prognosis and treatment efficacy remain urgently needed. Methods Expression profiles of lactylation related genes were analyzed utilizing the Cancer Genome Atlas (TCGA) database and BLCA data from the GSE13507 dataset. Two distinct clusters were...

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PMID: 40735323
DOI: 10.3389/fimmu.2025.1585727

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