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Article

DHCR7 as a Prognostic and Immunological Biomarker in Human Pan-Cancer: A Comprehensive Evaluation.

Cancer reports (Hoboken, N.J.) - 1 Nov 2025

Wu Xianghua, Zheng Weiwei, Wang Li, Lin Dan, Wu Zhaoxing

Abstract excerpt

BACKGROUND: The 7-Dehydrocholesterol reductase (DHCR7), a critical enzyme catalyzing the final step of the cholesterol biosynthesis pathway, has gained attention for its potential role in tumorigenesis. This study systematically investigated the association between DHCR7 expression and oncogenic processes across multiple cancer types. METHODS: Multi-omics data were obtained from The Cancer Genome Atlas (TCGA) and...

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Source

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Identifiers

PMID: 41198144
DOI: 10.1002/cnr2.70376
PMCID: PMC12591708

Genes

DHCR7
CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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