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Article

Integrated multi-dimensional analysis highlights DHCR7 mutations involving in cholesterol biosynthesis and contributing therapy of gastric cancer.

Journal of experimental & clinical cancer research : CR - 30 Jan 2023

Chen Yuqi, Yan Wenying, Yang Kexi, Qian Yiting, Chen Yanjun, Wang Ruoqin, Zhu Jinghan, He Yuxin, Wu Hongya, Zhang Guangbo, Shi Tongguo, Chen Weichang

Abstract excerpt

BACKGROUND: Genetic background plays an important role in the occurrence and development of gastric cancer (GC). With the application of genome-wide association study (GWAS), an increasing number of tumor susceptibility genes in gastric cancer have been discovered. While little of them can be further applicated in clinical diagnosis and treatment due to the lack of in-depth analysis. METHODS: A GWAS of peripheral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36710342
DOI: 10.1186/s13046-023-02611-6
PMCID: PMC9885627

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