Article

Focal adhesion kinase regulates early steps of myofibrillogenesis in cardiomyocytes

2018-02-07

Abstract excerpt

Forces generated by myofibrils within cardiomyocytes must be balanced by adhesion to the substrate and to other cardiomyocytes for proper heart function. Loss of this force balance results in cardiomyopathies that ultimately cause heart failure. How this force balance is first established during the assembly of myofibrils is poorly understood. Using human induced pluripotent stem cell derived cardiomyocytes, we sh...

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Literature Corpus work: 38e2d87d-3312-5493-a66a-ac086d6ab752
DOI: 10.1101/261248

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