Article

Identifying Changes to RNA Editome in Major Depressive Disorder

2018-09-18

Abstract excerpt

Major Depressive Disorder (MDD) is one of the most significant psychiatric disorders in the world today. Its incidence is widespread in society and its heavy adverse impact on the quality of life is well documented. Previously genetic studies on MDD had identified a hereditary component of the disease as well as crediting RNA editing with a role in its development. The later due to an overexpression of a heavily e...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38b492ee-401f-5433-81f9-22a8edea2131
DOI: 10.1101/419309

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying Changes to RNA Editome in Major Depressive DisorderDOI 10.1101/419309Read

Differential ADAR editing landscapes in major depressive disorder and suicideSemantic proximity Read

RNA Editing of the Human Serotonin 5-HT2C Receptor Alterations in Suicide and Implications for Serotonergic PharmacotherapySemantic proximity Read

RNA editing of serotonin 2C receptor in human postmortem brains of major mental disordersSemantic proximity Read

A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicideSemantic proximity Read

Serotonin 2c receptor RNA editing in major depression and suicideSemantic proximity Read

Serotonin receptor 2C and mental disorders: genetic, expression and RNA editing studies.Semantic proximity Read

Sparse whole-genome sequencing identifies two loci for major depressive disorderSemantic proximity Read

Exome-wide screening identifies novel rare risk variants for major depression disorder.Semantic proximity Read

Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings.Semantic proximity Read

Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in >1.2 million individuals highlight new therapeutic directions.Semantic proximity Read

Functional relevance of serotonin 2C receptor mRNA editing in antidepressant- and anxiety-like behaviorsSemantic proximity Read

Region-specific alterations of A-to-I RNA editing of serotonin 2c receptor in the cortex of suicides with major depressionSemantic proximity Read