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Article

RNase L-induced bodies sequester subgenomic flavivirus RNAs to promote viral RNA decay

27 Aug 2024

Abstract excerpt

Subgenomic flavivirus RNAs (sfRNAs) are structured RNAs encoded by flaviviruses that promote viral infection by inhibiting cellular RNA decay machinery. Herein, we analyze sfRNA production and localization using single-molecule RNA fluorescence in situ hybridization (smRNA-FISH) throughout West Nile virus, Zika virus, or dengue virus serotype 2 infection. We observe that sfRNAs are generated during the RNA...

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PMID: 39196777
DOI: 10.1016/j.celrep.2024.114694

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