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RNA-GPS Predicts SARS-CoV-2 RNA Residency to Host Mitochondria and Nucleolus

20 Jun 2020

Abstract excerpt

SARS-CoV-2 genomic and subgenomic RNA (sgRNA) transcripts hijack the host cell's machinery. Subcellular localization of its viral RNA could, thus, play important roles in viral replication and host antiviral immune response. We perform computational modeling of SARS-CoV-2 viral RNA subcellular residency across eight subcellular neighborhoods. We compare hundreds of SARS-CoV-2 genomes with the human transcriptome...

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PMID: 32673562
DOI: 10.1016/j.cels.2020.06.008

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