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A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection

2021-03-15

Abstract excerpt

Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) uses full-length angiotensin converting enzyme 2 (ACE2), which is membrane bound, as its initial cell contact receptor preceding viral entry. Here we report a human soluble ACE2 variant fused with a 5kD albumin binding domain (ABD) and bridged via a dimerization motif hinge-like 4-cysteine dodecapeptide, which we term ACE2 1-618-DDC-ABD. This protei...

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Identifiers and source

Literature Corpus work
3893af45-8095-547d-98c2-05bfa010c50e
DOI
10.1101/2021.03.12.435191
Open publication

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A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infectionDOI 10.1101/2021.03.12.435191
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