Article

Single-oocyte transcriptional profile of early-stage human oocytes reveals differentially expressed genes in the primordial and transitioning stages

2025-07-03

Abstract excerpt

<title>Abstract</title> <p>The critical initial step in human oocyte maturation - the transition of ovarian follicles from dormancy to activation - remains poorly understood. Here we performed RNA sequencing on single oocytes isolated from early-stage follicles from nine healthy reproductive-age donors. Data for 133 high-quality oocytes formed two connected clusters, C1 and C2, with 5,449 significantly differenti...

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Literature Corpus work: 388d0ddc-dee7-5dea-b274-6f1b509ecf09
DOI: 10.21203/rs.3.rs-6957514/v1

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