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Macrophage-derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistence

2025-06-05

Abstract excerpt

In this study, we reveal that macrophage-derived reactive oxygen species (ROS) can trigger the rapid formation of Salmonella aggresomes, which substantially contribute to the increased frequency of persisters induced by phagocytosis. Salmonella containing aggresomes exhibited a dormant phenotype characterized by reduced adenosine triphosphate (ATP) levels and decreased metabolic activity. Furthermore, these dorm...

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Identifiers and source

Literature Corpus work
3835a3e7-ac5b-5bf9-86b9-4a0aa03f460e
DOI
10.1101/2025.06.03.657582
Open publication

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Macrophage-derived reactive oxygen species promote <i>Salmonella</i> aggresome formation contributing to bacterial antibiotic persistenceDOI 10.1101/2025.06.03.657582
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