Article

Midbrain dopamine neuronal activity modulates splenic immunity through a brain-to-body circuit

2024-12-10

Abstract excerpt

Midbrain dopamine neurons are well-known to shape central nervous system function, yet there is growing evidence for their influence on the peripheral immune system. Here we demonstrate that midbrain dopamine neurons form a circuit to the spleen via a multi-synaptic pathway from the dorsal vagal complex (DVC) through the celiac ganglion. Midbrain dopamine neurons modulate the activity of D1- and D2-like dopamine r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38341fc8-e461-5581-8867-10302d909976
DOI: 10.1101/2024.12.05.625471

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Midbrain dopamine neuronal activity modulates splenic immunity through a brain-to-body circuitDOI 10.1101/2024.12.05.625471Read

Regulation of neurological and neuropsychiatric phenotypes by locus coeruleus-derived galanin.Semantic proximity Read

TLR9-activated B cells improve their regulatory function by endogenously produced catecholaminesSemantic proximity Read

Gut Lymphocyte Phenotype Changes After Parenteral Nutrition and Neuropeptide Administration.Semantic proximity Read

T Cells Plead for Rejuvenation and Amplification; With the Brain’s Neurotransmitters and Neuropeptides We Can Make It HappenSemantic proximity Read

Neuroendocrine‐Immune InteractionsSemantic proximity Read

Epigenetic Regulation of Inflammation by Dopamine in Primary Human MacrophagesSemantic proximity Read

A role of trace amine-associated receptors in the immune system functionSemantic proximity Read

A subset of dorsal raphe dopamine neurons is critical for survival-oriented vigilanceSemantic proximity Read

Splenic denervation attenuates repeated social defeat stress-induced T-lymphocyte inflammationSemantic proximity Read

Sympathetic nervous system control of anti-influenza CD8 <sup>+</sup> T cell responsesSemantic proximity Read

Hunger-promoting hypothalamic neurons modulate effector and regulatory T-cell responses.Semantic proximity Read

Effects of spleen nerve denervation on depression-like phenotype, systemic inflammation, and abnormal composition of gut microbiota in mice after administration of lipopolysaccharide: A role of brain-spleen axis.Semantic proximity Read