Article

Genome editing for treatment of <i>JAK2</i> V617F-driven myeloproliferative neoplasms

2025-12-19

Abstract excerpt

JAK2 V617F is a common haematological driver mutation and underlies most cases of myeloproliferative neoplasms (MPNs). Reducing variant allele frequency (VAF) is an important treatment goal, but no current treatment modalities fully and specifically inhibit mutant signalling. Thus, the consequences of V617F inactivation are unclear, including whether selective inhibition of V617F signalling will eradicate mutant c...

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Literature Corpus work: 3830232b-479d-5c44-b39b-4318190782aa
DOI: 10.64898/2025.12.17.694595

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