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Article

Sustained elevation of Snail promotes glial-mesenchymal transition after irradiation in malignant glioma

18 Dec 2013

Abstract excerpt

BACKGROUND: Ionizing irradiation is an effective treatment for malignant glioma (MG); however, a higher rate of recurrence with more aggressive phenotypes is a vital issue. Although epithelial-mesenchymal transition (EMT) is involved in irradiation-induced cancer progression, the role for such phenotypic transition in MG remains unknown. METHODS: To investigate the mechanism of irradiation-dependent tumor...

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PMID: 24357458
DOI: 10.1093/neuonc/not239

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