Article

Dermal fibroblasts from patients with Parkinson’s disease have normal GCase activity and autophagy compared to patients with PD and GBA mutations

2018-02-09

Abstract excerpt

<h4>Background: </h4> Recently, the development of Parkinson’s disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. <h4>Methods: </h4>: We investigated PD and Gaucher Disease (GD) patient derived skin fibroblasts using biochemistry assays. <h4>Results: </h4>: PD patient derived skin fibroblasts have normal glucocerebrosidase (GCase) act...

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Literature Corpus work: d463548e-7cf3-52d5-a31e-4613b561640a
DOI: 10.12688/f1000research.12090.2

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