Article

Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice

2017-02-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and objective</h4> Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is an effective therapeutic agent for non-small cell lung cancer with EGFR mutations. It can cause severe acute pneumonitis in some patients. We previously demonstrated that mice with naphthalene-induced airway epithelial injury developed severe gefitinib-induced pneumonitis an...

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Literature Corpus work: 37096aea-5221-50da-b57a-2e792d2ce9ad
DOI: 10.1101/108464

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