Article

Siglec-15 is a glyco-immune checkpoint in prostate cancer regulating immune evasion and metastasis

2026-08-10

Abstract excerpt

Prostate cancer is a leading cause of cancer-related mortality in men, and effective treatment options are limited for advanced and metastatic disease. The sialoglycan immune checkpoint Siglec-15 has emerged as a key mediator of tumour-associated immune suppression in several malignancies; however, its expression and functional role in prostate cancer remain poorly defined. Here, using dual immunofluorescence and...

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Literature Corpus work: 369aa6cf-ee51-5288-97df-aeaf21c5d228
DOI: 10.64898/2026.08.07.743480

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