Article

IL-15 synergizes with CD40 agonist antibodies to induce durable immunity against bladder cancer

2023-02-01

Abstract excerpt

CD40 is a central co-stimulatory receptor implicated in the development of productive anti-tumor immune responses across multiple cancers, including bladder cancer. Despite strong preclinical rationale, systemic administration of therapeutic agonistic antibodies targeting the CD40 pathway have demonstrated dose limiting toxicities with minimal clinical activity to date, emphasizing an important need for optimized...

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Literature Corpus work: 1bdf9876-66f0-584f-b507-100383ff6858
DOI: 10.1101/2023.01.30.526266

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