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Localized Delivery of an IL-2–Expressing Oncolytic Vaccinia Virus Enhances PD-1 Pathway Inhibition in a De-Novo Esophageal Adenocarcinoma Model

2026-07-25

Abstract excerpt

<title>Abstract</title> <p>Background/Objectives: Esophageal adenocarcinoma (EAC) is a highly lethal malignancy with limited response to immune checkpoint blockade (ICB) despite its benefits in select patients. Oncolytic viruses (OVs) offer a promising immunotherapy platform by inducing tumor lysis and stimulating anti-tumor immunity. We previously demonstrated that a genetically engineered oncolytic vaccinia vi...

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Literature Corpus work
367ecd15-fdba-5682-827f-33a4ee93760e
DOI
10.21203/rs.3.rs-10232137/v1
Open publication

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Localized Delivery of an IL-2–Expressing Oncolytic Vaccinia Virus Enhances PD-1 Pathway Inhibition in a De-Novo Esophageal Adenocarcinoma ModelDOI 10.21203/rs.3.rs-10232137/v1
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