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A genetic screen identifies a protective type III interferon response to <i>Cryptosporidium</i> that requires TLR3 dependent recognition

2021-10-06

Abstract excerpt

Cryptosporidium is a leading cause of severe diarrhea and diarrheal-related death in children worldwide. As an obligate intracellular parasite, Cryptosporidium relies on intestinal epithelial cells to provide a niche for its growth and survival, but little is known about the contributions that the infected cell makes to this relationship. Here we conducted a genome wide CRISPR/Cas9 knockout screen to discover hos...

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Literature Corpus work
36605d24-1ffc-5143-9d65-05c2d10763b1
DOI
10.1101/2021.10.06.463303
Open publication

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A genetic screen identifies a protective type III interferon response to <i>Cryptosporidium</i> that requires TLR3 dependent recognitionDOI 10.1101/2021.10.06.463303
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