Article

Investigating the genetic relationship between vitamin B12 deficiency and Parkinson’s disease

2025-01-02

Abstract excerpt

<h4>Introduction</h4> Epidemiological studies suggest that patients with Parkinson’s disease (PD) may have lower levels of vitamin B12 compared to healthy controls, and it was proposed that PD patients could benefit from vitamin B12 supplementation. Functional studies have shown that B12 could modify LRRK2 activity and may directly interact with alpha-synuclein. This study aimed to investigate the role of common a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3627f689-6e31-5dfe-94a5-63730dc75a83
DOI: 10.1101/2025.01.01.25319858

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Investigating the genetic relationship between vitamin B12 deficiency and Parkinson’s diseaseDOI 10.1101/2025.01.01.25319858Read

Common genetic variants associated with risk of Parkinson's disease in non-European populations: a PROSPERO registered systematic review based on genome-wide association studiesSemantic proximity Read

Genetic Determinants of Parkinson's Disease: Can They Help to Stratify the Patients Based on the Underlying Molecular Defect?Semantic proximity Read

Analysis of rare Parkinson’s disease variants in millions of peopleSemantic proximity Read

Gene Signals and SNPs Associated with Parkinson's Disease: A Nutrigenomics and Computational Prospective Insights.Semantic proximity Read

Penetrance of Parkinson’s disease in<i>GBA1</i>carriers is depending on the variant severity and polygenic backgroundSemantic proximity Read

Analysis of rare Parkinson’s disease variants in millions of peopleSemantic proximity Read

Genetic Risk Profiling in Parkinson's Disease and Utilizing Genetics to Gain Insight into Disease-Related Biological Pathways.Semantic proximity Read

Assessing the role of polygenic background on the penetrance of monogenic forms in Parkinson’s diseaseSemantic proximity Read

Vitamin D deficiency and genetic polymorphisms of Vitamin D-associated genes in Parkinson's DiseaseSemantic proximity Read

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson’s Disease RiskSemantic proximity Read

Genetic landscape of Parkinson’s disease and related diseases in LuxembourgSemantic proximity Read

Rare-Variant Burden Analysis of Dystonia Genes in Parkinson’s DiseaseSemantic proximity Read