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<i>Schistosoma mansoni</i> antigen induced innate immune memory features mitochondrial biogenesis and can be inhibited by ovarian produced hormones

2025-01-18

Abstract excerpt

We have previously identified that S. mansoni infection induces a unique form of myeloid training that protects male but not female mice from high fat diet induced disease. Here we demonstrate that ovarian derived hormones account for this sex specific difference. Ovariectomy of females prior to infection permits metabolic reprogramming of the myeloid lineage, with BMDM exhibiting carbon source flexibility for ce...

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Literature Corpus work
3609b028-06ef-5c6b-a134-b37934bde646
DOI
10.1101/2025.01.14.632838
Open publication

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