Article

ETEC heat-labile toxin promotes β-catenin stabilization and transcriptional reprogramming to disrupt intestinal epithelial differentiation

2025-10-03

Abstract excerpt

Enterotoxigenic Escherichia coli (ETEC), defined by their production of heat-labile (LT) and heat-stable (ST) enterotoxins, are a common cause of acute diarrheal illness in children from low- and middle- income countries, and are also linked to long-term sequelae such as malnutrition, and growth impairment. While the mechanisms underlying toxin-mediated acute diarrhea are known, the molecular events involved in E...

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Literature Corpus work: 35d43994-0228-5c0a-b793-67419a406a61
DOI: 10.1101/2025.10.02.680135

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