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Prospective prediction of clinical drug response in high-grade gliomas using an ex vivo 3D cell culture assay

1 Jan 2021

Abstract excerpt

Abstract Background Clinical outcomes in high-grade glioma (HGG) have remained relatively unchanged over the last 3 decades with only modest increases in overall survival. Despite the validation of biomarkers to classify treatment response, most newly diagnosed (ND) patients receive the same treatment regimen. This study aimed to determine whether a prospective functional assay that provides a direct, live tumor...

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PMID: 34142085
DOI: 10.1093/noajnl/vdab065

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