The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

doi:10.1194/jlr.c400002-jlr200

Article

The orphan nuclear receptor LRH-1 activates the ABCG5/ABCG8 intergenic promoter

8 Jun 2004

Abstract excerpt

The ATP binding cassette (ABC) half-transporters ABCG5 and ABCG8 facilitate biliary and intestinal removal of neutral sterols. Here, we identify a binding site for the orphan nuclear receptor liver receptor homolog-1 (LRH-1) at nt 134-142 of the ABCG5/ABCG8 intergenic region necessary for the activity of both the ABCG5 and ABCG8 promoters. Mutating this LRH-1 binding site reduced promoter activity of the human...

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