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Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanism

2025-05-01

Abstract excerpt

<h4>Background</h4> Metastatic colorectal cancer (mCRC) is associated with high recurrence rates and resistance to conventional treatments, largely driven by cancer stem cells (CSCs) that contribute to tumor progression and therapeutic evasion. This study aims to investigate the role of netrin-1 and its dependence receptor UNC5B in regulating CSC self-renewal in mCRC and explore their potential as therapeutic tar...

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Literature Corpus work
e180a5bf-c610-5d0b-9311-bae3e14000d4
DOI
10.1101/2025.04.28.650943
Open publication

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Netrin-1 regulates colorectal cancer stem cell self-renewal via a TFF3 dependent paracrine survival mechanismDOI 10.1101/2025.04.28.650943
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