Article

VPRBP functions downstream of the androgen receptor and OGT to restrict p53 activation in prostate cancer

2021-02-28

Abstract excerpt

A comprehensive understanding of androgen receptor (AR) signalling mechanisms during prostate carcinogenesis is instrumental in developing novel therapies. Studies have shown glycosylation as a key androgen regulated process and that O-GlcNAc transferase (OGT), the enzyme that catalyses the covalent addition of UDP-N-acetylglucosamine (UDP-GlcNAc) to serine and threonine residues of proteins, is often up-regulated...

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Literature Corpus work: 341c52d9-5759-5813-8a75-cb2bfac70dfb
DOI: 10.1101/2021.02.28.433236

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