Article

Reactive astrocytes associated with prion disease impair the blood brain barrier

2023-03-25

Abstract excerpt

<h4>Background</h4> Impairment of the blood-brain barrier (BBB) is considered to be a common feature among neurodegenerative diseases, including Alzheimer’s, Parkinson’s and prion diseases. In prion disease, increased BBB permeability was reported 40 years ago, yet the mechanisms behind the loss of BBB integrity have never been explored. Recently, we showed that reactive astrocytes associated with prion diseases...

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Literature Corpus work: 33cb08c5-0432-5fd5-bab8-11784e966a6d
DOI: 10.1101/2023.03.21.533684

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