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The prophase oocyte nucleus is a homeostatic G-actin buffer

3 Feb 2022

Abstract excerpt

Formation of healthy mammalian eggs from oocytes requires specialised F-actin structures. F-actin disruption produces aneuploid eggs, which are a leading cause of human embryo deaths, genetic disorders and infertility. We found that oocytes contain prominent nuclear F-actin structures that are correlated with meiotic developmental capacity. We demonstrate that nuclear F-actin is a conserved feature of healthy...

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PMID: 35112707
DOI: 10.1242/jcs.259807

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