Article

Catalysis of cataract-associated human γD crystallin aggregation via dynamic disulfide exchange

2018-04-12

Abstract excerpt

Several mutations in human γD-crystallin (HγD), a long-lived eye lens protein, cause misfolding and aggregation, leading to cataract. Surprisingly, wild-type HγD catalyzes aggregation of its cataract related W42Q variant while itself remaining soluble – the inverse of the classical prion-like scenario whereby misfolded polypeptides catalyze aggregation of natively folded ones. The search for a biochemical mechanis...

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Literature Corpus work: 975febe7-c13c-549c-ad39-dcdf3f8e17c7
DOI: 10.1101/300608

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