Article

Mutational selection: fragile sites, replicative stress, and genome evolution

2023-08-21

Abstract excerpt

New mutations compete in the germline with their unmutated progenitors. Successful genes accumulate functions that are easily broken by small mutational changes, thus placing their own mutants at a selective disadvantage. Their germline phenotypes evolve to be fragile rather than robust to the effects of mutation. Genetic recombination, by contrast, favors robust interactions among parts that must maintain functio...

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Literature Corpus work: 336b1723-b37b-5a42-a9db-8d9446abbcc2
DOI: 10.32388/9eryw5

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