Article

Rapid but nondurable response of a BRAF exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors

2024-05-03

Abstract excerpt

Introduction: BRAF V600E substitution predicts sensitivity of a cancer to BRAF inhibitor therapy. The mutation is rarely found in soft-tissue sarcomas. Here we describe a case of undifferentiated spindle cell sarcoma showing primary insensitivity to standard chemotherapy and pronounced but non-sustained response to BRAF/MEK inhibitors at recurrence. Case presentation: A 13-year-old girl was diagnosed with low-gra...

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Literature Corpus work: 33535a41-e129-5690-be9a-645c99106281
DOI: 10.22541/au.171470114.42572781/v1

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