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Article

BRAF mutation in 'sarcomas': a possible method to detect de-differentiated melanomas.

Histopathology - 1 Apr 2014

Cipriani Nicole A, Letovanec Igor, Hornicek Francis J, Mullen John T, Duan Zhenfeng, Borger Darrell R, Nielsen Gunnlaugur Petur

Abstract excerpt

AIMS: BRAF is mutated in 50-60% of melanomas, but BRAF mutation in sarcomas has not been systematically evaluated. Some melanomas are spindled and may show no immunohistochemical evidence of melanocytic differentiation. Similarly, many sarcomas are undifferentiated, i.e. undifferentiated pleomorphic sarcomas (UPS). Diagnosing melanoma versus sarcoma in an undifferentiated spindle cell malignancy can be...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24117833
DOI: 10.1111/his.12305

Genes

BRAF

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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