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Article

Rapid but nondurable response of a BRAF exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors.

Oncotarget - 17 Jul 2024

Sinichenkova Kseniya, Sidorov Iliya, Kriventsova Nataliya, Konovalov Dmitriy, Abasov Ruslan, Usman Nataliya, Karachunskiy Alexander, Novichkova Galina, Litvinov Dmitriy, Druy Alexander

Abstract excerpt

INTRODUCTION: BRAF V600E substitution predicts sensitivity of a cancer to BRAF inhibitor therapy. The mutation is rarely found in soft-tissue sarcomas. Here we describe a case of undifferentiated spindle cell sarcoma showing primary insensitivity to standard chemotherapy and pronounced but non-sustained response to BRAF/MEK inhibitors at recurrence. CASE PRESENTATION: A 13-year-old girl was diagnosed with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39018206
DOI: 10.18632/oncotarget.28606
PMCID: PMC11254299

Genes

BRAF

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