Article
BRAF V600E mutation is a potential therapeutic target for a small subset of synovial sarcoma.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Sept 2020
Watanabe Sho, Shimomura Akihiko, Kubo Takashi, Sekimizu Masaya, Seo Takuji, Watanabe Shun-Ichi, Kawai Akira, Yamamoto Noboru, Tamura Kenji, Kohno Takashi, Ichikawa Hitoshi, Yoshida Akihiko
Abstract excerpt
Synovial sarcoma (SS) is an aggressive tumor that most often affects the deep soft tissues in young adults. Intrathoracic SS is rare and is associated with poor outcome, highlighting the urgent need for a novel therapeutic strategy. In the process of clinical sequencing, we identified two patients with intrathoracic SS harboring the BRAF V600E mutation. The patients were women aged 32 and 23 years, and both...
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