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Article

Rapid and Efficient Genome Editing in Staphylococcus aureus by Using an Engineered CRISPR/Cas9 System.

Journal of the American Chemical Society - 15 Mar 2017

Chen Weizhong, Zhang Yifei, Yeo Won-Sik, Bae Taeok, Ji Quanjiang

Abstract excerpt

Staphylococcus aureus, a major human pathogen, has been the cause of serious infectious diseases with a high mortality rate. Although genetics is a key means to study S. aureus physiology, such as drug resistance and pathogenesis, genetic manipulation in S. aureus is always time-consuming and labor-intensive. Here we report a CRISPR/Cas9 system (pCasSA) for rapid and efficient genome editing, including gene...

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PMID: 28218837
DOI: 10.1021/jacs.6b13317

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