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Article

‘Where is my gap’: mechanisms underpinning PARP inhibitor sensitivity in cancer

1 Feb 2025

Abstract excerpt

The introduction of poly-ADP ribose polymerase (PARP) inhibitors (PARPi) has completely changed the treatment landscape of breast cancer susceptibility 1-2 (BRCA1-BRCA2)-mutant cancers and generated a new avenue of research in the fields of DNA damage response and cancer therapy. Despite this, primary and secondary resistances to PARPi have become a challenge in the clinic, and novel therapies are urgently needed...

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PMID: 39927794
DOI: 10.1042/bst20241633

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