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Dissecting the Causal Pathway from the Gut Microbiota to PCOS via Circulating Metabolite Mediation: Evidence from Mendelian Randomization, Single-cell and Bulk RNA Sequencing, Network Pharmacology, and In Vitro Tissue Validation

2025-07-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Backgroud</bold> Alterations in the gut microbiota have been increasingly linked to the pathogenesis of polycystic ovary syndrome (PCOS), but the causal relationships and underlying molecular mechanisms remain poorly understood. <bold>Methods</bold> We employed a bidirectional two-sample Mendelian randomization (MR) approach to assess causal associations among the gut microbi...

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Literature Corpus work
32bc07c9-0f91-54dd-a54d-2e49f16935c3
DOI
10.21203/rs.3.rs-7028262/v1
Open publication

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Dissecting the Causal Pathway from the Gut Microbiota to PCOS via Circulating Metabolite Mediation: Evidence from Mendelian Randomization, Single-cell and Bulk RNA Sequencing, Network Pharmacology, and In Vitro Tissue ValidationDOI 10.21203/rs.3.rs-7028262/v1
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