Genetically predicted inflammatory cytokines mediate the associations between the gut microbiota and ovarian cancer: a bidirectional two-sample Mendelian randomization study.

Abstract excerpt

BACKGROUND: Ovarian cancer (OC), the deadliest gynecologic malignancy, lacks effective strategies for early detection and treatment. Emerging evidence suggests that the gut microbiota and inflammatory cytokines may influence OC pathogenesis, but the causal mechanisms remain unclear. This study employed a bidirectional, two-sample Mendelian randomization (MR) analysis with genetic mediation analysis to investigate...

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